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Description for Protein CAD

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
8 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.1.3.2; 3.5.2.3; 6.3.5.5
KEGG - Orthology:
K11540
KEGG - Pathway(s):
hsa00240; hsa00250; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Carbomyl phosphate synthetase/aspartate transcarbamoylase/dihydroorotase; CAD trifuntional protein; CPSase/ATCase/DHOase
Approved Symbol:
CAD
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 18
Human (de-) phosphorylation sites: 18; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 1
Human phosphorylation targets: 1; Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • L-Aspartic Acid(db);
  • L-Glutamine(db);
  • N-(Phosphonacetyl)-L-Aspartic Acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06437 Entrez Gene ID: 790 OMIM ID: 114010 Swissprot Accession: P27708;