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Description for Protein CXCR4

chemokine (C-X-C motif) receptor 4
34 total interacting proteins; 25 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 2)
Summary:
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04189
    KEGG - Pathway(s):
    hsa04060; hsa04062; hsa04144; hsa04360; hsa04670; hsa04672
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Chemokine receptor 4; Seven transmembrane helix receptor; Chemokine (C-X-C motif) receptor 4 isoform b; Chemokine (C-X-C motif) receptor 4 isoform a; NPY3R; LESTR; LCR1; NPYR; WHIM; HSY3RR; NPYY3R; C-X-C chemokine receptor type 4; SDF-1 receptor; Neuropeptide Y receptor Y3; Fusin; D2S201E; Leukocyte derived seven transmembrane domain receptor; Seven transmembrane segment receptor, spleen; HM89; Lipopolysaccharide associated protein 3; LAP3; LPS associated protein 3; Stromal cell derived factor 1 receptor; CD184 antigen; FB22; NPYRL
    Approved Symbol:
    CXCR4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 33
    Human (de-) phosphorylation sites: 33; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Framycetin(db);
  • Plerixafor(db)

    Associated Genetic Diseases:

  • Whim syndrome(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 7
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 01217 Entrez Gene ID: 7852 OMIM ID: 162643 Swissprot Accession: P61073; Q53S69;