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Description for Protein MOGS

mannosyl-oligosaccharide glucosidase
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 2)
Summary:
This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.2.1.106
    KEGG - Orthology:
    K01228
    KEGG - Pathway(s):
    hsa00510; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Mannosyl oligosaccharide glucosidase; Processing A glucosidase 1; GCS1
    Approved Symbol:
    MOGS
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Glucosidase I deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 03214 Entrez Gene ID: 7841 OMIM ID: 601336 Swissprot Accession: Q13724; Q58F09;