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Description for Protein CACNB2

calcium channel, voltage-dependent, beta 2 subunit
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a subunit of a voltage-dependent calcium channel protein which is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome which is an autoimmune disorder. Mutations in this gene are associated with Brugada symdrome. Alternatively spliced variants have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH3: Src homology 3 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04863
    KEGG - Pathway(s):
    hsa04010; hsa04260; hsa05410; hsa05412; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Calcium channel, voltage-dependent, beta 2 subunit isoform 7; Calcium channel, voltage-dependent, beta 2 subunit isoform 6; Calcium channel, voltage-dependent, beta 2 subunit isoform 8; Calcium channel, voltage-dependent, beta 2 subunit isoform 3; Calcium channel, voltage-dependent, beta 2 subunit isoform 5; Calcium channel, voltage-dependent, beta 2 subunit isoform 2; Calcium channel, voltage-dependent, beta 2 subunit isoform 4; CAB2; MYSB; CACNLB2; Calcium channel beta 2 subunit; Myasthenic syndrome antigen B; Lambert-eaton myasthenic syndrome antigen; Voltage dependent calcium channel beta 2 subunit; Dihydropyridine sensitive L type calcium channel beta 2 subunit; Calcium channel, voltage-dependent, beta 2 subunit isoform 1
    Approved Symbol:
    CACNB2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 40
    Human (de-) phosphorylation sites: 40; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amlodipine(db);
  • Felodipine(db);
  • Isradipine(db);
  • Magnesium Sulfate(db);
  • Mibefradil(db);
  • Nicardipine(db);
  • Nifedipine(db);
  • Nilvadipine(db);
  • Nimodipine(db);
  • Nisoldipine(db);
  • Nitrendipine(db);
  • Verapamil(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02473 Entrez Gene ID: 783 OMIM ID: 600003 Swissprot Accession: Q59H42; Q5QJ99; Q08289;