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Description for Protein CACNB1

calcium channel, voltage-dependent, beta 1 subunit
4 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH3: Src homology 3 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04862
    KEGG - Pathway(s):
    hsa04010; hsa04260; hsa05410; hsa05412; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Calcium channel, voltage dependent, beta 1 subunit isoform 2; Calcium channel, voltage dependent, beta 1 subunit isoform 3; Voltage dependent L type calcium channel beta 1 subunit; CAB1; CACNLB1; Dihydropyridine sensitive L type, calcium channel beta 1 subunit; Calcium channel, L type, beta 1; Calcium channel, neuronal dihydropyridine sensitive, beta subunit; CCHLB; CCHLB1; MGC41896; Calcium channel, voltage-dependent, beta 1 subunit isoform 1
    Approved Symbol:
    CACNB1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amlodipine(db);
  • Ibutilide(db);
  • Magnesium Sulfate(db);
  • Mibefradil(db);
  • Nimodipine(db);
  • Verapamil(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11743 Entrez Gene ID: 782 OMIM ID: 114207 Swissprot Accession: B3KXG1; Q02641;