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Description for Protein CACNA1S

calcium channel, voltage-dependent, L type, alpha 1S subunit
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04857
    KEGG - Pathway(s):
    hsa04010; hsa04020; hsa04260; hsa04270; hsa04912; hsa05010; hsa05410; hsa05412; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; CACNL1A3; CCHL1A3; calcium channel, skeletal muscle dihydropyridine-sensitive, alpha-1 subunit; MHS5; HOKPP
    Approved Symbol:
    CACNA1S
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amlodipine(db);
  • Cinnarizine(db);
  • Felodipine(db);
  • Isradipine(db);
  • Magnesium Sulfate(db);
  • Mibefradil(db);
  • Nifedipine(db);
  • Nilvadipine(db);
  • Nimodipine(db);
  • Nisoldipine(db);
  • Nitrendipine(db);
  • Verapamil(db)

    Associated Genetic Diseases:

  • Hypokalemic periodic paralysis(Pd);
  • Malignant hyperthermia, susceptibility to, 5(Pd);
  • Thyrotoxic periodic paralysis, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
    00248_1(19)
    Additional Identifiers:

    HPRD: 00248 Entrez Gene ID: 779 OMIM ID: 114208 Swissprot Accession: Q13698;