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Description for Protein CACNA1E

calcium channel, voltage-dependent, R type, alpha 1E subunit
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants of the gene described here have been observed but have not been thoroughly characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04852
    KEGG - Pathway(s):
    hsa04010; hsa04020; hsa04930
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    BII; CACH6; Cav2.3; CACNL1A6; Brain calcium channel II; Voltage gated calcium channel alpha subunit Cav2.3; Calcium channel, L type, alpha 1 polypeptide, isoform 6; Voltage dependent R type calcium channel alpha 1E subunit
    Approved Symbol:
    CACNA1E
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
    03006_1(19)
    Additional Identifiers:

    HPRD: 03006 Entrez Gene ID: 777 OMIM ID: 601013 Swissprot Accession: Q15878;