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Description for Protein CACNA1C

calcium channel, voltage-dependent, L type, alpha 1C subunit
10 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • TNF: Tumour necrosis factor family.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04850
    KEGG - Pathway(s):
    hsa04010; hsa04020; hsa04260; hsa04270; hsa04720; hsa04912; hsa04930; hsa05010; hsa05410; hsa05412; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CaV1.2; CACN2; CACH2; CCHL1A1; CACNL1A1; DHPR, alpha 1 subunit; Voltage gated calcium channel alpha subunit Cav1.2; Calcium channel, cardiac dihydropyridine sensitive, alpha 1C subunit
    Approved Symbol:
    CACNA1C
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 29
    Human (de-) phosphorylation sites: 29; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amlodipine(db);
  • Calcium(db);
  • Cinnarizine(db);
  • Drotaverine(db);
  • Felodipine(db);
  • Ibutilide(db);
  • Isradipine(db);
  • Magnesium Sulfate(db);
  • Mibefradil(db);
  • Nicardipine(db);
  • Nifedipine(db);
  • Nilvadipine(db);
  • Nimodipine(db);
  • Nisoldipine(db);
  • Nitrendipine(db);
  • Verapamil(db)

    Associated Genetic Diseases:

  • Timothy syndrome(Pd)
    		• Predicted Transmembrane Domains:
    00246_20(21)
    00246_19(19)
    00246_18(19)
    00246_17(19)
    00246_16(19)
    00246_15(19)
    00246_14(19)
    00246_13(19)
    00246_12(19)
    00246_11(19)
    00246_10(19)
    00246_9(19)
    00246_8(19)
    00246_7(19)
    00246_6(21)
    00246_5(19)
    00246_4(19)
    00246_3(19)
    00246_2(21)
    00246_1(19)
    Additional Identifiers:

    HPRD: 00246 Entrez Gene ID: 775 OMIM ID: 114205 Swissprot Accession: Q13936;