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Description for Protein CACNA1B

calcium channel, voltage-dependent, N type, alpha 1B subunit
10 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Voltage-dependent Ca(2+) channels are multisubunit complexes found in the membrane of many excitable cells that regulate calcium entry (see MIM 601011). N-type calcium channels, which control neurotransmitter release from neurons, are dihydropyridine-insensitive and omega-conotoxin-sensitive. The alpha-1 subunit forms the pore through which calcium enters the cell, and is encoded by a family of at least 5 genes.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04849
    KEGG - Pathway(s):
    hsa04010; hsa04020; hsa04742; hsa04930
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CACNL1A5; Voltage dependent N type calcium channel alpha 1B subunit; Calcium channel L type alpha 1 polypeptide, isoform 5; Brain calcium channel III; BIII; CACH5
    Approved Symbol:
    CACNA1B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amlodipine(db);
  • Gabapentin(db);
  • Levetiracetam(db);
  • Verapamil(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
    03005_1(21)
    Additional Identifiers:

    HPRD: 03005 Entrez Gene ID: 774 OMIM ID: 601012 Swissprot Accession: Q00975; Q59FJ3;