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Description for Protein TRIM25

tripartite motif-containing 25
21 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 1)
Summary:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RING: Ring finger
  • CC: Coiled Coil
  • PRY: Parathyroid hormone
  • SPRY: Domain in SPla and the RYanodine Receptor.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10652
    KEGG - Pathway(s):
    hsa04622
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Estrogen responsive finger protein; Tripartite motif protein 25; EFP; RNF147; Z147; ZNF147
    Approved Symbol:
    TRIM25
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02711 Entrez Gene ID: 7706 OMIM ID: 600453 Swissprot Accession: Q14258;