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Description for Protein CA4

carbonic anhydrase IV
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    4.2.1.1
    KEGG - Orthology:
    K01672
    KEGG - Pathway(s):
    hsa00910; hsa04964
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Carbonate dehydratase IV; CA IV; EC 4.2.1.1
    Approved Symbol:
    CA4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (4s-Trans)-4-(Ethylamino)-5,6-Dihydro-6-Methyl-4h-Thieno(2,3-B)Thiopyran-2-Sulfonamide-7,7-Dioxide(db);
  • Acetazolamide(db);
  • Bendroflumethiazide(db);
  • Benzthiazide(db);
  • Brinzolamide(db);
  • Chlorothiazide(db);
  • Cyclothiazide(db);
  • Dichlorphenamide(db);
  • Dorzolamide(db);
  • Ethoxzolamide(db);
  • Hydrochlorothiazide(db);
  • Hydroflumethiazide(db);
  • Methazolamide(db);
  • Methyclothiazide(db);
  • Topiramate(db);
  • Trichlormethiazide(db);
  • Zonisamide(db)

    Associated Genetic Diseases:

  • Retinitis pigmentosa 17(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00261 Entrez Gene ID: 762 OMIM ID: 114760 Swissprot Accession: P22748; Q6FHI7;