 Platelet Evidence
(proteome studies/others : 12/1)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 8; secretome: 2) |
Summary:
CA2 is one of several (at least 7) isozymes of carbonic anhydrase. Carbonic anhydrase catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. [provided by RefSeq] (PubMed Links)
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| Domains and Motifs:
Gene Ontology:
KEGG - Enzyme ID(s):
KEGG - Orthology:
K01672
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Nomenclature / Alternative Names:
Carbonic anhydrase B; Carbonic anhydrase C; Carbonic dehydratase; Carbonate dehydratase II; EC 4.2.1.1; Carbonic anhydrase II, erthrocyte, electrophoretic variants of, included
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Approved Symbol:
| (De-) Phosphorylations:
| Total (de-) phosphorylation sites: 0 |
| No human (de-) phosphorylation sites; | No platelet phosphorylation sites |
Phosphorylation Targets:
| Total phosphorylation targets: 0 |
| Human phosphorylation targets: 0; | Predicted platelet targets: 0 |
| Protein Characteristics:
|  Associated Drugs (DrugBank Accession):
(17beta)-17-(cyanomethyl)-2-methoxyestra-1(10),2,4-trien-3-yl sulfamate(db);
(4-sulfamoyl-phenyl)-thiocarbamic acid O-(2-thiophen-3-yl-ethyl) ester(db);
(4aS,4bR,10bS,12aS)-12a-methyl-1,3-dioxo-2-(pyridin-3-ylmethyl)-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydronaphtho[2,1-f]isoquinolin-8-yl sulfamate(db);
(4s-Trans)-4-(Ethylamino)-5,6-Dihydro-6-Methyl-4h-Thieno(2,3-B)Thiopyran-2-Sulfonamide-7,7-Dioxide(db);
(4s-Trans)-4-(Methylamino)-5,6-Dihydro-6-Methyl-4h-Thieno(2,3-B)Thiopyran-2-Sulfonamide-7,7-Dioxide(db);
(9BETA,13ALPHA,14BETA,17ALPHA)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIYL DISULFAMATE(db);
(R)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide(db);
(S)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide(db);
1,2,4-Triazole(db);
1-Methyl-3-Oxo-1,3-Dihydro-Benzo[C]Isothiazole-5-Sulfonic Acid Amide(db);
1-N-(4-SULFAMOYLPHENYL-ETHYL)-2,4,6-TRIMETHYLPYRIDINIUM(db);
2,6-Difluorobenzenesulfonamide(db);
2-(1,3-thiazol-4-yl)-1H-benzimidazole-5-sulfonamide(db);
2-(cycloheptylmethyl)-1,1-dioxido-1-benzothiophen-6-yl sulfamate(db);
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide(db);
2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide(db);
3,5-Difluorobenzenesulfonamide(db);
3-Mercuri-4-Aminobenzenesulfonamide(db);
3-Nitro-4-(2-Oxo-Pyrrolidin-1-Yl)-Benzenesulfonamide(db);
3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID(db);
4,5-DICHLOROBENZENE-1,3-DISULFONAMIDE(db);
4-(2-AMINOETHYL)BENZENESULFONAMIDE(db);
4-(5-METHYL-3-PHENYLISOXAZOL-4-YL)BENZENESULFONAMIDE(db);
4-(Aminosulfonyl)-N-[(2,3,4-Trifluorophenyl)Methyl]-Benzamide(db);
4-(Aminosulfonyl)-N-[(2,4,6-Trifluorophenyl)Methyl]-Benzamide(db);
4-(Aminosulfonyl)-N-[(2,4-Difluorophenyl)Methyl]-Benzamide(db);
4-(Aminosulfonyl)-N-[(2,5-Difluorophenyl)Methyl]-Benzamide(db);
4-(Aminosulfonyl)-N-[(3,4,5-Trifluorophenyl)Methyl]-Benzamide(db);
4-(Aminosulfonyl)-N-[(4-Fluorophenyl)Methyl]-Benzamide(db);
4-(Hydroxymercury)Benzoic Acid(db);
4-({[(4-METHYLPIPERAZIN-1-YL)AMINO]CARBONOTHIOYL}AMINO)BENZENESULFONAMIDE(db);
4-chloro-N-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamide(db);
4-Flourobenzenesulfonamide(db);
4-Methylimidazole(db);
4-Sulfonamide-[1-(4-Aminobutane)]Benzamide(db);
4-Sulfonamide-[4-(Thiomethylaminobutane)]Benzamide(db);
4-[(3-BROMO-4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLE(db);
4-[(4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLE(db);
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide(db);
5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID(db);
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide(db);
5-{[(4-AMINO-3-CHLORO-5-FLUOROPHENYL)SULFONYL]AMINO}-1,3,4-THIADIAZOLE-2-SULFONAMIDE(db);
6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE(db);
6-ethoxy-1,3-benzothiazole-2-sulfonamide(db);
6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE(db);
6-Oxo-8,9,10,11-Tetrahydro-7h-Cyclohepta[C][1]Benzopyran-3-O-Sulfamate(db);
Acetate Ion(db);
Acetazolamide(db);
Al-6619, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Hydroxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide](db);
Al-6629, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Methoxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide](db);
AL4623(db);
AL5300(db);
AL5424(db);
AL5927(db);
AL6528(db);
Al7089a(db);
AL7099A(db);
AL7182(db);
Aminodi(Ethyloxy)Ethylaminocarbonylbenzenesulfonamide(db);
Bendroflumethiazide(db);
Benzthiazide(db);
Beta-Mercaptoethanol(db);
Brinzolamide(db);
Chlorothiazide(db);
Cyanamide(db);
Cyclothiazide(db);
Dansylamide(db);
Diazoxide(db);
Dichlorphenamide(db);
Dorzolamide(db);
Ethinamate(db);
Ethoxzolamide(db);
ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE(db);
Formic Acid(db);
Hydrochlorothiazide(db);
Hydroflumethiazide(db);
indane-5-sulfonamide(db);
Mercuribenzoic Acid(db);
Methazolamide(db);
Methyclothiazide(db);
Methyl Mercury Ion(db);
N-(2,3,4,5,6-Pentaflouro-Benzyl)-4-Sulfamoyl-Benzamide(db);
N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE(db);
N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-Benzamide(db);
N-(2-Flouro-Benzyl)-4-Sulfamoyl-Benzamide(db);
N-(2-Thienylmethyl)-2,5-Thiophenedisulfonamide(db);
N-({[4-(AMINOSULFONYL)PHENYL]AMINO}CARBONYL)-4-METHYLBENZENESULFONAMIDE(db);
N-Benzyl-4-Sulfamoyl-Benzamide(db);
N-[(2R)-5-(aminosulfonyl)-2,3-dihydro-1H-inden-2-yl]-2-propylpentanamide(db);
N-[2-(1h-Indol-5-Yl)-Butyl]-4-Sulfamoyl-Benzamide(db);
N-[4-(AMINOSULFONYL)PHENYL]-2-MERCAPTOBENZAMIDE(db);
N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE(db);
PHENYLALANYLAMINODI(ETHYLOXY)ETHYL BENZENESULFONAMIDEAMINOCARBONYLBENZENESULFONAMIDE(db);
Quinethazone(db);
Sulfamic Acid 2,3-O-(1-Methylethylidene)-4,5-O-Sulfonyl-Beta-Fructopyranose Ester(db);
SULTHIAME(db);
THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE)(db);
Topiramate(db);
Trichlormethiazide(db);
Urea(db);
Zonisamide(db)
Associated Genetic Diseases:
Carbonic anhydrase II deficiency(Pd); Carbonic anhydrase II variant(Pd)
| Predicted Transmembrane Domains:
| Additional Identifiers:
| HPRD: | 02023 | | Entrez Gene ID: | 760 | | OMIM ID: | 611492 | | Swissprot Accession: | P00918; | | |
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