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Description for Protein CA1

carbonic anhydrase I
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 4/0)
(microparticles: 1; platelet: 2; secretome: 1)
Summary:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Variants of this gene have been described in some populations. Multiple alternatively spliced variants, encoding the same protein, have been identified. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
4.2.1.1
KEGG - Orthology:
K01672
KEGG - Pathway(s):
hsa00910
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
CA I; Carbonic anhydrase I, erythrocyte, electrophoretic variants of; Carbonic anhydrase A; EC 4.2.1.1
Approved Symbol:
CA1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID(db);
  • Acetazolamide(db);
  • Amlodipine(db);
  • Bendroflumethiazide(db);
  • Benzthiazide(db);
  • Brinzolamide(db);
  • Chlorothiazide(db);
  • Cyclothiazide(db);
  • Diazoxide(db);
  • Dichlorphenamide(db);
  • Dorzolamide(db);
  • Ethinamate(db);
  • Ethoxzolamide(db);
  • ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE(db);
  • Hydrochlorothiazide(db);
  • Hydroflumethiazide(db);
  • Methazolamide(db);
  • Methocarbamol(db);
  • Methyclothiazide(db);
  • N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE(db);
  • Quinethazone(db);
  • Trichlormethiazide(db);
  • Zonisamide(db)

    Associated Genetic Diseases:

  • Carbonic anhydrase I, Guam(Pd);
  • Carbonic anhydrase I, Icaria(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00265 Entrez Gene ID: 759 OMIM ID: 114800 Swissprot Accession: P00915;