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Description for Protein ZAP70

zeta-chain (TCR) associated protein kinase 70kDa
52 total interacting proteins; 25 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH2: Src homology 2 domains
  • Tyr_Kinase: tyrosine kinase domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.2
    KEGG - Orthology:
    K07360
    KEGG - Pathway(s):
    hsa04650; hsa04660; hsa05340
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Zeta-chain (TCR) associated protein kinase (70 kD); SRK; STD; TZK; EC 2.7.1.112; 70 kDa zeta associated protein; Truncated ZAP kinase; Syk-related tyrosine kinase; Zeta-chain associated protein kinase, 70kD
    Approved Symbol:
    ZAP70
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 32
    Human (de-) phosphorylation sites: 32; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 10
    Human phosphorylation targets: 10; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Staurosporine(db)

    Associated Genetic Diseases:

  • Selective T-cell defect, immunodeficiency due to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01495 Entrez Gene ID: 7535 OMIM ID: 176947 Swissprot Accession: P43403;