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Description for Protein YWHAZ

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
184 total interacting proteins; 78 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 11/2)
(membrane: 2; microparticles: 1; platelet: 7; secretome: 2; undefined: 1)
Summary:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06630
    KEGG - Pathway(s):
    hsa04110; hsa04114; hsa04722; hsa05130
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Protein kinase C inhibitor protein 1; KCIP-1; Factor activating exoenzyme S; FAS; Phospholipase A2; Tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; 14-3-3 protein/cytosolic phospholipase A2
    Approved Symbol:
    YWHAZ
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03183 Entrez Gene ID: 7534 OMIM ID: 601288 Swissprot Accession: P63104; D0PNI1;