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Description for Protein YWHAH

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
73 total interacting proteins; 25 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/2)
(alpha granules: 1; membrane: 2; microparticles: 1; platelet: 5; secretome: 1; undefined: 1)
Summary:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K06630
KEGG - Pathway(s):
hsa04110; hsa04114; hsa04722
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Tyrosine 3 monooxygenase/Tryptophan 5 monooxygenase activation protein, eta isoform; Brain protein 14-3-3, eta isoform; Tyrosine 3-monooxygenase/Tryptophan 5-monooxygenase activation protein 1; YWHA1; Protein AS1
Approved Symbol:
YWHAH
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 6
Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00215 Entrez Gene ID: 7533 OMIM ID: 113508 Swissprot Accession: Q04917; Q9H4N8;