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Description for Protein YWHAG

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
283 total interacting proteins; 125 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/1)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 4; secretome: 1; undefined: 1)
Summary:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K06630
KEGG - Pathway(s):
hsa04110; hsa04114; hsa04722
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, gamma isoform; Protein kinase C inhibitor protein 1; KCIP 1
Approved Symbol:
YWHAG
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 7
Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05639 Entrez Gene ID: 7532 OMIM ID: 605356 Swissprot Accession: P61981;