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Description for Protein YWHAE

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
104 total interacting proteins; 41 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 10/1)
(membrane: 2; microparticles: 1; platelet: 6; secretome: 1; undefined: 1)
Summary:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K06630
KEGG - Pathway(s):
hsa04110; hsa04114; hsa04722
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
KCIP1; Protein kinase C inhibitor protein 1; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon isoform; Tyrosine 3/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; 14-3-3 protein, epsilon isoform; 14-3-3E; SR3-9; Suppressor of RAS1 3-9; Mitochondrial import stimulation factor, L subunit; MDS; MDCR
Approved Symbol:
YWHAE
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 10
Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Fusicoccin(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05457 Entrez Gene ID: 7531 OMIM ID: 605066 Swissprot Accession: P62258; Q4VJB6;