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Description for Protein YWHAB

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
142 total interacting proteins; 64 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/1)
(membrane: 2; microparticles: 1; platelet: 4; secretome: 2; undefined: 1)
Summary:
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06630
    KEGG - Pathway(s):
    hsa04110; hsa04114; hsa04722
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Protein kinase C inhibitor protein-1; GW128; HS1; KCIP-1; Protein 1054; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide protein 1054; 14-3-3 protein beta/alpha; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide variant
    Approved Symbol:
    YWHAB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03184 Entrez Gene ID: 7529 OMIM ID: 601289 Swissprot Accession: P31946;