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Description for Protein YES1

v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
36 total interacting proteins; 23 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/2)
(membrane: 1; platelet: 2; undefined: 2)
Summary:
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH2: Src homology 2 domains
  • Tyr_Kinase: tyrosine kinase domain
  • SH3: Src homology 3 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.2
    KEGG - Orthology:
    K05705
    KEGG - Pathway(s):
    hsa04520; hsa04530
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    cellular yes-1 protein; Yamaguchi sarcoma oncogene; proto-oncogene tyrosine-protein kinase YES; Yes; HsT441; P61-YES
    Approved Symbol:
    YES1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 24
    Human (de-) phosphorylation sites: 24; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 4
    Human phosphorylation targets: 4; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Dasatinib(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01285 Entrez Gene ID: 7525 OMIM ID: 164880 Swissprot Accession: P07947;