Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein XRCC5

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
55 total interacting proteins; 19 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • Ku78: Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen
  • VWA: von Willebrand factor (vWF) type A domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10885
    KEGG - Pathway(s):
    hsa03450
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Ku80; Ku86; TLAA; CTCBF; CTC85; KARP-1; Nuclear factor IV; Thyroid-lupus autoantigen; Ku antigen, 80-KD subunit; 86 kDa subunit of Ku antigen; ATP-dependant DNA helicase II; Lupus Ku autoantigen protein p86; Ku86 autoantigen related protein 1; CTC box binding factor 85 kDa subunit; NFIV; DNA repair protein XRCC5
    Approved Symbol:
    XRCC5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08935 Entrez Gene ID: 7520 OMIM ID: 194364 Swissprot Accession: P13010;