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Description for Protein XDH

xanthine dehydrogenase
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.17.1.4; 1.17.3.2
KEGG - Orthology:
K00106
KEGG - Pathway(s):
hsa00230; hsa00232; hsa00983; hsa01100; hsa04146
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Xanthine oxidase; Xanthine dehydrogenase; XOD
Approved Symbol:
XDH
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 3
Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-(3-Cyano-4-Isobutoxy-Phenyl)-4-Methyl-5-Thiazole-Carboxylic Acid(db);
  • 4-[5-Pyridin-4-Yl-1h-[1,2,4]Triazol-3-Yl]-Pyridine-2-Carbonitrile(db);
  • Allopurinol(db);
  • dioxothiomolybdenum(VI) ion(db);
  • Flavin-Adenine Dinucleotide(db);
  • Y-700(db)

    Associated Genetic Diseases:

  • Xanthinuria, type I(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06363 Entrez Gene ID: 7498 OMIM ID: 607633 Swissprot Accession: P47989;