Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein WHSC1

Wolf-Hirschhorn syndrome candidate 1
7 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SET: SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  • PHD: PHD zinc finger
  • NLS: Nuclear localization signal
  • PWWP: domain with conserved PWWP motif
  • HMG: high mobility group
  • CC: Coiled Coil
  • EGFL: EGF domain, unclasssified subfamily
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.1.1.43
    KEGG - Orthology:
    K11424
    KEGG - Pathway(s):
    hsa00310
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Wolf hirschhorn syndrome candidate 1; NSD2; Multiple myeolma SET domain; MMSET; IL5 promoter REII region binding protein; Trithorax/ash1 related protein 5; TRX5; REIIBP; Wolf Hirschhorn syndrome candidate 1 protein isoform 3; Wolf Hirschhorn syndrome candidate 1 protein isoform 4; Wolf Hirschhorn syndrome candidate 1 protein isoform 5; Wolf-Hirschhorn syndrome candidate 1 protein isoform 1; KIAA1090
    Approved Symbol:
    WHSC1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 24
    Human (de-) phosphorylation sites: 24; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
    04259_10(0)
  • Isoform 9 : 0
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04259 Entrez Gene ID: 7468 OMIM ID: 602952 Swissprot Accession: O96028; A2A2T4;