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Description for Protein VWF

von Willebrand factor
14 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/3)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 5; secretome: 2; undefined: 2)
Summary:
The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • VWA: von Willebrand factor (vWF) type A domain
  • VWD: von Willebrand factor (vWF) type D domain
  • VWC: von Willebrand factor (vWF) type C domain
  • CT: C-terminal cystine knot-like domain (CTCK)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03900
    KEGG - Pathway(s):
    hsa04510; hsa04512; hsa04610
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Coagulation factor VIII VWF; vWF
    Approved Symbol:
    VWF
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Antihemophilic Factor(db)

    Associated Genetic Diseases:

  • Von Willebrand disease, type I(Pd);
  • Von Willebrand disease, type IIA(Pd);
  • Von Willebrand disease, type IIB(Pd);
  • Von Willebrand disease, type IIC(Pd);
  • Von Willebrand disease, type IID(Pd);
  • Von Willebrand disease, type III(Pd);
  • Von Willebrand disease, type IIM(Pd);
  • Von Willebrand factor Normandy 1(Pd);
  • Von Willebrand factor Normandy 2(Pd);
  • Von Willebrand factor Normandy 3(Pd);
  • Von Willebrand factor polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01906 Entrez Gene ID: 7450 OMIM ID: 193400 Swissprot Accession: P04275;