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Description for Protein VEGFA

vascular endothelial growth factor A
21 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • PDGF: Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05448
    KEGG - Pathway(s):
    hsa04060; hsa04150; hsa04370; hsa04510; hsa05200; hsa05211; hsa05212; hsa05219
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Vascular endothelial growth factor A; Vascular permeability factor
    Approved Symbol:
    VEGFA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Bevacizumab(db);
  • Carvedilol(db);
  • Gliclazide(db);
  • Lenalidomide(db);
  • Minocycline(db);
  • Pyroglutamic Acid(db);
  • Ranibizumab(db);
  • Tris(Hydroxymethyl)Aminomethane(db)

    Associated Genetic Diseases:

  • Atherosclerosis, susceptibility to(Pd);
  • Diabetic retinopathy, NIDDM-related, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01889 Entrez Gene ID: 7422 OMIM ID: 192240 Swissprot Accession: P15692;