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Description for Protein VDAC2

voltage-dependent anion channel 2
7 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/2)
(membrane: 2; microparticles: 1; phosphoproteome: 1; platelet: 11; undefined: 1)
Summary:
This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K05862
KEGG - Pathway(s):
hsa04020; hsa05012; hsa05016
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Voltage dependent anion channel 2; hVDAC2; Outer mitochondrial membrane protein porin 2; FLJ23841; Eukaryotic porin
Approved Symbol:
VDAC2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 14
Human (de-) phosphorylation sites: 14; Platelet phosphorylation sites: 2
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Dihydroxyaluminium(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01904 Entrez Gene ID: 7417 OMIM ID: 193245 Swissprot Accession: P45880;