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Description for Protein VDAC1

voltage-dependent anion channel 1
27 total interacting proteins; 15 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 10/1)
(membrane: 2; microparticles: 1; phosphoproteome: 1; platelet: 6; undefined: 1)
Summary:
This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y. (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K05862
KEGG - Pathway(s):
hsa04020; hsa05012; hsa05016
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Voltage dependent anion channel 1; Porin; OMP2 human complement of; hVDAC1; Outer mitochondrial membrane protein porin 1; Voltage dependent anion selective channel protein 1; Plasmalemmal porin; Porin 31HL; Porin 31HM; MGC111064
Approved Symbol:
VDAC1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 10
Human (de-) phosphorylation sites: 10; Platelet phosphorylation sites: 1
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Dihydroxyaluminium(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05137 Entrez Gene ID: 7416 OMIM ID: 604492 Swissprot Accession: P21796;