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Description for Protein VCP

valosin-containing protein
56 total interacting proteins; 26 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 11/1)
(alpha granules: 1; ATP binding: 1; membrane: 2; microparticles: 1; platelet: 6; secretome: 1; undefined: 1)
Summary:
The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • AAA: ATPases associated with a variety of cellular activities
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K13525
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    p97; TERA; Transitional endoplasmic reticulum ATPase; IBMPFD
    Approved Symbol:
    VCP
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 56
    Human (de-) phosphorylation sites: 56; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine-5'-Diphosphate(db);
  • Phosphoaminophosphonic Acid-Adenylate Ester(db)

    Associated Genetic Diseases:

  • Inclusion body myopathy with early-onset paget disease(Pd);
  • Inclusion body myopathy with early-onset paget disease and frontotemporal dementia(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03013 Entrez Gene ID: 7415 OMIM ID: 601023 Swissprot Accession: Q96IF9; P55072;