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Description for Protein VCL

vinculin
27 total interacting proteins; 18 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 14/3)
(alpha granules: 1; membrane: 2; microparticles: 1; platelet: 10; secretome: 2; undefined: 2)
Summary:
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05700
    KEGG - Pathway(s):
    hsa04510; hsa04520; hsa04670; hsa04810; hsa05100; hsa05131
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Vinculin isoform VCL; Vinculin isoform meta-VCL; MVCL; Metavinculin
    Approved Symbol:
    VCL
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 23
    Human (de-) phosphorylation sites: 23; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01900 Entrez Gene ID: 7414 OMIM ID: 193065 Swissprot Accession: P18206; B3KXA2;