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Description for Protein VAV1

vav 1 guanine nucleotide exchange factor
74 total interacting proteins; 45 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 2)
Summary:
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CH: Calponin homology domain
  • RHOGEF: Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
  • CC: Coiled Coil
  • PH: Pleckstrin homology domain.
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • SH3: Src homology 3 domains
  • SH2: Src homology 2 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05730
    KEGG - Pathway(s):
    hsa04062; hsa04510; hsa04650; hsa04660; hsa04662; hsa04664; hsa04666; hsa04670; hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    VAV1 oncogene; Oncogene VAV
    Approved Symbol:
    VAV1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01284 Entrez Gene ID: 7409 OMIM ID: 164875 Swissprot Accession: P15498;