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Description for Protein VASP

vasodilator-stimulated phosphoprotein
30 total interacting proteins; 21 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 11/3)
(membrane: 2; microparticles: 1; phosphoproteome: 1; platelet: 7; secretome: 1; undefined: 2)
Summary:
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • WH1: WASP homology region 1
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06274
    KEGG - Pathway(s):
    hsa04510; hsa04666; hsa04670
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Vasodilator-stimulated phosphoprotein isoform 1; Vasodilator-stimulated phosphoprotein isoform 2
    Approved Symbol:
    VASP
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03415 Entrez Gene ID: 7408 OMIM ID: 601703 Swissprot Accession: P50552;