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Description for Protein UROD

uroporphyrinogen decarboxylase
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 2)
Summary:
This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria. (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
4.1.1.37
KEGG - Orthology:
K01599
KEGG - Pathway(s):
hsa00860
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Uroporphyrinogen III decarboxylase; UPD
Approved Symbol:
UROD
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 5
Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Beta-Mercaptoethanol(db);
  • Coproporphyrin I(db);
  • Coproporphyrin Iii(db)

    Associated Genetic Diseases:

  • Porphyria cutanea tarda(Pd);
  • Porphyria, hepatoerythropoietic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01441 Entrez Gene ID: 7389 OMIM ID: 176100 Swissprot Accession: P06132;