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Description for Protein UQCRB

ubiquinol-cytochrome c reductase binding protein
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
This gene encodes a protein which is part of the ubiquinol-cytochrome c oxidoreductase complex which contains ten nuclear-encoded and one mitochondrial-encoded subunits. The encoded protein binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. Mutations in this gene are associated with mitochondrial complex III deficiency. A pseudogene has been described on the X chromosome. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.10.2.2
KEGG - Orthology:
K00417
KEGG - Pathway(s):
hsa00190; hsa01100; hsa04260; hsa05010; hsa05012; hsa05016
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Ubiquinol cytochrome C reductase complex 14 kDa protein; Ubiquinone binding protein complex III subunit VI; QPC; UQBC; UQBP; UQPC; EC 1.10.2.2
Approved Symbol:
UQCRB
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE(db);
  • 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol(db);
  • 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE(db);
  • 5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE(db);
  • 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole(db);
  • B-Octylglucoside(db);
  • FAMOXADONE(db);
  • METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE(db);
  • METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE(db);
  • UBIQUINONE-2(db)

    Associated Genetic Diseases:

  • Mitochondrial complex III deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11770 Entrez Gene ID: 7381 OMIM ID: 191330 Swissprot Accession: P14927;