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Description for Protein UMPS

uridine monophosphate synthetase
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 8)
Summary:
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.4.2.10; 4.1.1.23
KEGG - Orthology:
K13421
KEGG - Pathway(s):
hsa00240; hsa00983; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Uridine monophosphate synthetase; UMP synthase; Orotate phosphoribosyltransferase; OPRtase; Orotidine 5`-phosphate decarboxylase; OMPdecase
Approved Symbol:
UMPS
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 6-Hydroxyuridine-5'-Phosphate(db)

    Associated Genetic Diseases:

  • Orotic aciduria(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02022 Entrez Gene ID: 7372 OMIM ID: 258900 Swissprot Accession: A8K5J1; P11172;