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Description for Protein UGT2B7

UDP glucuronosyltransferase 2 family, polypeptide B7
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The UGTs (EC 2.4.1.17) serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B7 has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. Its subcellular location is the microsome.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.4.1.17
    KEGG - Orthology:
    K00699
    KEGG - Pathway(s):
    hsa00040; hsa00053; hsa00140; hsa00500; hsa00830; hsa00860; hsa00980; hsa00982; hsa00983; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    UGT2B9; UDP glucuronosyl transferase 2 family, memeber B7; Uridine diphosphate glucuronosyl transferase 2 family, member B9; UDP glucuronosyltransferase 2 family, member B9; Uridine diphosphate glycosyltransferase 2 family, member B7
    Approved Symbol:
    UGT2B7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 02508 Entrez Gene ID: 7364 OMIM ID: 600068 Swissprot Accession: P16662;