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Description for Protein UCHL1

ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
17 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease. (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.4.19.12
KEGG - Orthology:
K05611
KEGG - Pathway(s):
hsa05012
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Ubiquitin C-Terminal Hydrolase, Neuron-Specific; PGP9.5; Ubiquitin carboxyl terminal hydrolase isozyme L1
Approved Symbol:
UCHL1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Parkinson disease(Pd);
  • Parkinson disease, resistance to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01877 Entrez Gene ID: 7345 OMIM ID: 191342 Swissprot Accession: P09936;