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Description for Protein SUMO1

SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
85 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • UBQ: Ubiquitin homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12160
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    SMT3H3; SMT3C; Sentrin; PIC1; UBL1; Ubiquitin like 1; GMP1; SENP2; SMT3; GAP modifying protein 1; Small ubiquitin-like modifier 1; SMT3 suppressor of mif two 3 homolog 1 isoform a precursor; SMT3 suppressor of mif two 3 homolog 1 isoform b precursor; OFC10; SUMO1
    Approved Symbol:
    SUMO1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Orofacial cleft 10(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03554 Entrez Gene ID: 7341 OMIM ID: 601912 Swissprot Accession: A8MUS8; P63165;