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Description for Protein UBE2V1

ubiquitin-conjugating enzyme E2 variant 1
26 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(membrane: 1; platelet: 4)
Summary:
Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Multiple alternatively spliced transcripts encoding different isoforms have been described for this gene. A pseudogene has been identified which is also located on chromosome 20. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • UBC: Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10704
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    UEV1; UEV1A; CROC1; TRAF6-regulated IKK activator 1 beta Uev1A; UBE2V; Ubiquitin-conjugating enzyme E2 variant 1 isoform a; Ubiquitin-conjugating enzyme E2 variant 1 isoform c; CIR1; Ubiquitin-conjugating enzyme variant Kua; ubiquitin-conjugating enzyme E2 Kua-UEV isoform 2; ubiquitin-conjugating enzyme E2 variant 1 isoform d
    Approved Symbol:
    UBE2V1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04294 Entrez Gene ID: 7335 OMIM ID: 602995 Swissprot Accession: Q13404;