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Description for Protein UBE2L3

ubiquitin-conjugating enzyme E2L 3
34 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 2)
Summary:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • UBC: Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.2.19
    KEGG - Orthology:
    K04552
    KEGG - Pathway(s):
    hsa04120; hsa05012
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    UBCH7; Ubiquitin conjugating enzyme UBCH7; Ubiquitin protein ligase; Ubiquitin carrier protein; UbcM4; E2-F1; L-UBC; Ubiquitin conjugating enzyme E2-18 kDa UbcH7; ubiquitin-conjugating enzyme E2L 3 isoform 1; ubiquitin-conjugating enzyme E2L 3 isoform 2; EC 6.3.2.19
    Approved Symbol:
    UBE2L3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04762 Entrez Gene ID: 7332 OMIM ID: 603721 Swissprot Accession: P68036;