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Description for Protein UBE2D2

ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
103 total interacting proteins; 27 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • UBC: Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.2.19
    KEGG - Orthology:
    K06689
    KEGG - Pathway(s):
    hsa04120; hsa05131
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    UBC4/5, homolog of; Ubiquitin conjugating enzyme UBCH5B; UBCH5B; UBC4; E2(17)KB 2; Ubiquitin-conjugating enzyme E2; Ubiquitin protein ligase; Ubiquitin carrier protein; Similar to ubiquitin-conjugating enzyme E2D 2; PUBC1; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-conjugating enzyme E2 D2 transcript variant 1; Ubiquitin carrier protein D2; EC 6.3.2.19; Ubiquitin-conjugating enzyme E2D 2 isoform 2; Ubiquitin-conjugating enzyme E2D 2 isoform 1
    Approved Symbol:
    UBE2D2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (R,R)-2,3-Butanediol(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04268 Entrez Gene ID: 7322 OMIM ID: 602962 Swissprot Accession: P62837; Q96RP6;