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Description for Protein TYRP1

tyrosinase-related protein 1
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.18.-
    KEGG - Orthology:
    K00506
    KEGG - Pathway(s):
    hsa00350; hsa01100; hsa04916
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TYRP; TRP; Catalase B; CATB; CAS2; Glycoprotein 75; GP75; b-protein; EC 1.14.18.-
    Approved Symbol:
    TYRP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Albinism, oculocutaneous, type III(Pd);
  • Rufous oculocutaneous albinism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00283 Entrez Gene ID: 7306 OMIM ID: 115501 Swissprot Accession: P17643;