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Description for Protein TYRO3

TYRO3 protein tyrosine kinase
7 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • Ig_LIKE: Immunoglobulin like
  • FN3: Fibronectin type 3 domain
  • TM: Transmembrane domain
  • Tyr_Kinase: tyrosine kinase domain
  • IGC2: Immunoglobulin C-2 Type
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.1
    KEGG - Orthology:
    K05116
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Protein tyrosine kinase 3; Tyrosine protein kinase receptor; Tyrosine protein kinase RSE; Tyrosine protein kinase SKY; Tyrosine protein kinase DTK; Protein tyrosine kinase byk; Brt; Dtk; Sky; Tif; RSE; BYK
    Approved Symbol:
    TYRO3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Acetate Ion(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 02641 Entrez Gene ID: 7301 OMIM ID: 600341 Swissprot Accession: Q06418;