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Description for Protein TYMS

thymidylate synthetase
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.1.1.45
KEGG - Orthology:
K00560
KEGG - Pathway(s):
hsa00240; hsa00670; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Thymidylate synthase; TS; TMS; TSase; dTMP synthase
Approved Symbol:
TYMS
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 10-Propargyl-5,8-Dideazafolic Acid(db);
  • 2'-deoxyuridylic acid(db);
  • 6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE(db);
  • 6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE(db);
  • Beta-Mercaptoethanol(db);
  • Capecitabine(db);
  • Floxuridine(db);
  • Fluorouracil(db);
  • Gemcitabine(db);
  • Leucovorin(db);
  • N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide(db);
  • N-[2-chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide(db);
  • Pemetrexed(db);
  • Raltitrexed(db);
  • S,S-(2-Hydroxyethyl)Thiocysteine(db);
  • Thymidine-5'-Phosphate(db);
  • Trifluridine(db);
  • Trimethoprim(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01774 Entrez Gene ID: 7298 OMIM ID: 188350 Swissprot Accession: P04818; Q53Y97;