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Description for Protein TXNRD1

thioredoxin reductase 1
6 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 1; secretome: 3)
Summary:
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.8.1.9
KEGG - Orthology:
K00384
KEGG - Pathway(s):
hsa00240
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
TXNR; TR1; Thioredoxin reductase, cytoplasmic; EC 1.8.1.9; TR; TRXR1; GRIM-12; MGC9145; Thioredoxin reductase 1 isoform 3; Thioredoxin reductase GRIM-12; KM-102-derived reductase-like factor
Approved Symbol:
TXNRD1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 24
Human (de-) phosphorylation sites: 24; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Arsenic trioxide(db);
  • Flavin-Adenine Dinucleotide(db);
  • Fotemustine(db);
  • Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate(db);
  • Spermidine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03068 Entrez Gene ID: 7296 OMIM ID: 601112 Swissprot Accession: Q16881;