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Description for Protein TSTA3

tissue specific transplantation antigen P35B
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 3; secretome: 2)
Summary:
Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.1.1.271
KEGG - Orthology:
K02377
KEGG - Pathway(s):
hsa00051; hsa00520; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase; Red cell NADP (H) binding protein; p35B; 3-5 epimerase/4-reductase; FX protein; GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase; Tissue specific transplantation antigen P35B; EC 1.1.1.271
Approved Symbol:
TSTA3
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • NADH(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00654 Entrez Gene ID: 7264 OMIM ID: 137020 Swissprot Accession: Q13630;