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Description for Protein TSHR

thyroid stimulating hormone receptor
24 total interacting proteins; 20 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04249
    KEGG - Pathway(s):
    hsa04080; hsa05320
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    LGR3; MGC75129; Thyrotropin receptor-I; Thyroid stimulating hormone receptor isoform 1; Thyroid stimulating hormone receptor isoform 2; TSH receptor; Thyrotropin receptor; TSH-R
    Approved Symbol:
    TSHR
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Thyrotropin Alfa(db)

    Associated Genetic Diseases:

  • Graves disease, susceptibility to(Pd);
  • Hyperthyroidism, familial gestational(Pd);
  • Hyperthyroidism, nonautoimmune(Pd);
  • Hypothyroidism, congenital, nongoitrous, 1(Pd);
  • Thyroid adenoma, hyperfunctioning, somatic(Pd);
  • Thyroid carcinoma with thyrotoxicosis(Pd);
  • Thyrotropin receptor polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 04537 Entrez Gene ID: 7253 OMIM ID: 603372 Swissprot Accession: P16473; A0PJU7; Q8TB90;