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Description for Protein TRPC6

transient receptor potential cation channel, subfamily C, member 6
15 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/2)
(membrane: 1; phosphoproteome: 1; platelet: 3; undefined: 2)
Summary:
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ANK: ankyrin repeats
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04969
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Transient receptor potential cation channel, subfamily C, member 6; Transient receptor potential channel 6; TRP6; Short transient receptor potential channel 6
    Approved Symbol:
    TRPC6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; Platelet phosphorylation sites: 2
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Glomerulosclerosis, focal segmental, 2(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 04710 Entrez Gene ID: 7225 OMIM ID: 603652 Swissprot Accession: Q9Y210;