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Description for Protein HSP90B1

heat shock protein 90kDa beta (Grp94), member 1
25 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 11/1)
(alpha granules: 1; ATP binding: 1; membrane: 2; microparticles: 1; platelet: 6; secretome: 1; undefined: 1)
Summary:
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90B1 is an endoplasmic reticulum HSP90 protein. Other HSP90 proteins are found in cytosol (see HSP90AA1; MIM 140571) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09487
    KEGG - Pathway(s):
    hsa04621; hsa05200; hsa05215
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Stress inducible tumor rejection antigen gp96; ECGP; GRP94
    Approved Symbol:
    HSP90B1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 18
    Human (de-) phosphorylation sites: 18; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-Methoxy-2-(2-Methoxyethoxy)Ethane(db);
  • 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE(db);
  • 2-Chlorodideoxyadenosine(db);
  • Adenosine-5'-Diphosphate(db);
  • METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE(db);
  • N-Ethyl-5'-Carboxamido Adenosine(db);
  • Radicicol(db);
  • Rifabutin(db);
  • Tetraethylene Glycol(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01860 Entrez Gene ID: 7184 OMIM ID: 191175 Swissprot Accession: P14625;