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Description for Protein C3

complement component 3
27 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/1)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 1; secretome: 3; undefined: 1)
Summary:
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • C345C: Netrin C-terminal Domain
  • ANATO: Anaphylatoxin homologous domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03990
    KEGG - Pathway(s):
    hsa04610; hsa05140; hsa05142; hsa05322
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    C3b; C3a; ASP; Acylation stimulating protein
    Approved Symbol:
    C3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Intravenous Immunoglobulin(db);
  • S-Hydroxycysteine(db)

    Associated Genetic Diseases:

  • C3 deficiency(Pd);
  • C3 polymorphism, HAV 4-1 plus/minus type(Pd);
  • C3S/C3F polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00400 Entrez Gene ID: 718 OMIM ID: 120700 Swissprot Accession: P01024;