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Description for Protein TPR

translocated promoter region (to activated MET oncogene)
14 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09291
    KEGG - Pathway(s):
    hsa05200; hsa05216
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Tumor potentiating region; Nucleoprotein TPR; Nuclear pore complex-associated protein TPR
    Approved Symbol:
    TPR
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 59
    Human (de-) phosphorylation sites: 59; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08927 Entrez Gene ID: 7175 OMIM ID: 189940 Swissprot Accession: P12270; Q99968;